Dr. Tengfei Guo

tengfei.guo@szbl.ac.cn

My group primarily employs multimodal neuroimaging and fluid biomarker technologies to investigate cognitively unimpaired older adults and patients with Alzheimer’s disease (AD). We are committed to elucidating the temporal evolution, pathological characteristics, and therapeutic targets of AD. Clinical findings and the underlying molecular mechanisms are further validated and investigated using patient-derived induced pluripotent stem cell (iPSC) models and AD animal models.

In 2021, I initiated the Greater Bay Area Healthy Aging Brain Study (GHABS), a standardized AD cohort comprising more than 2,000 participants. Using this cohort, we systematically characterized the longitudinal trajectories of fluid biomarkers and neuroimaging markers across the entire AD continuum, identified a series of promising targets for early diagnosis and intervention, established blood biomarker cutoffs tailored to the Chinese population, and developed digital cognitive assessment tools suitable for large-scale community-based cognitive screening in China.

Over the past few years, I have published more than 40 corresponding-author research articles in leading journals, including Lancet Neurology, JAMA Neurology, Nature Aging, Cell Reports Medicine and Molecular Neurodegeneration. I currently serve as Deputy Section Editor for Alzheimer's & Dementia and as Associate Editor for Alzheimer’s Research & Therapy. My research has been supported by the National Natural Science Foundation of China (Excellent Young Scientists Fund, Regional Joint Key Program, and General Program), the National Key Research and Development Program of China (Young Scientist), the Guangdong Provincial Excellent Young Scientists Fund, and the Shenzhen Excellent Young Scientists Fund.

Education and Experience

12/2020 - Present, Junior PI, Shenzhen Bay Laboratory

5/2018-11/2020, Postdoctoral Fellow, University of California, Berkeley, advised by Prof. William Jagust

11/2014 - 4/2018, PhD, Technical University of Munich, Germany, advised by Prof. Markus Schwaiger and Prof. Timo Grimmer

9/2013 - 9/2014, MSc in Medical Physics, Heidelberg University, Germany

9/2011 - 9/2013, M.E. in Biomedical Engineering, Shanghai Jiao Tong University,

9/2007 - 6/2011, B.E. in Medical information Engineering, Sichuan University

Research Interests

Aging, Alzheimer’s disease, and vascular disease

PET/CT imaging (Aβ, Tau, FDG), MRI imaging (T1, T2 FlAIR, Resting fMRI, DTI, ASL and etc.)

CSF/Plasma biomarkers

Neuroscience, neurobiology, iPSC

Neuromodulation

Fundings

National Key Research and Development Program of China, 2026-2030, ongoing, PI.

Nature Science Foundation of China (NSFC) for Excellent Young Scholars, 2025-2027, ongoing, PI.

Guangdong Science Foundation for Distinguished Young Scholars, 2023-2026, ongoing, PI.

Shenzhen basic research Foundation for Excellent Young Scholars, 2023-2026, ongoing, PI.

Nature Science Foundation of China (NSFC) General Project, 2022 to 2025, ongoing, PI.

Shenzhen Bay Laboratory Key Cultivating Project, 2021-2022, joint PI.

Shenzhen Bay Laboratory Open project, 2020-2023, joint PI.

Awards

2023, 2024, 2025 Alzheimer's Association Internaitonal Conference “Young Investigator Travel Scholarship”

2020 American Alzheimer’s Association “Young Investigator” Honorable Mention Award

2020 Human amyloid imaging “Young Investigator Travel Scholarship”

2018 Alavi-Mandell Publication Award, Society of Nuclear Medicine & Molecular Imaging (SNMMI)

Services

Association: International Alzheimer’s Association ISTAART “PIA to Elevate Early Career Researchers (PEERs)”, Asia lead, 2021-2024

Journal Editor: Alzheimer’s & Dementia (Deputy Section Editor); Alzheimer’s Research & Therapy (Associate Editor); Molecular Neurodegeneration (Editor Board); Advanced Brain (Editor Board)

Contact details