GUO LABORATORY 
Aging, Alzheimer's Disease, Biomarker, Neuroimaging

PUBLICATIONS
(* Corresponding author, # Equally contribution)
2025

Guoyu Lan#, Mengjie Wang#, Fernando Gonzalez-Ortiz#, Laihong Zhang#, Anqi Li, Binyin Li, Mingxing Jiang, Jie Yang, Xuhui Chen, Dai Shi, Xiang Fan, Yue Cai, Pan Sun, Lin Liu, Jieyin Li, Zhengbo He, Lili Fang, Xin Zhou, Linting Chen, Yiying Wang, Mingxu Li, Zhen Liu, Qingyong Wang, Linsen Xu, Liemin Zhou, Guanxun Cheng, Xinlu Wang, Pengcheng Ran, Lu Wang, Kun Sun, Ying Han, Yihui Guan, the Alzheimer’s Disease Neuroimaging Initiative, Kaj Blennow*, Fang Xie* and Tengfei Guo*. “Comprehensive Evaluation of Novel Plasma Tau Biomarkers for Detecting and Monitoring Alzheimer’s Disease in Multicenter and Multiethnic Aging Populations”, Nature Aging, 2025, DOI: 10.1038/s43587-025-00904-3.[Paper]


Dai Shi, Chenghui Ye, Anqi Li, Pan Sun, Guoyu Lan, Laihong Zhang, Xin Zhou, Liemin Zhou*, Zhen Liu*, and Tengfei Guo*. “Presynaptic loss and axonal degeneration synergistically correlate with longitudinal neurodegeneration and cognitive decline”, Alzheimer’s & Dementia, 2025, DOI: 10.1002/alz.70080.[Paper]


Pan Sun, Zhengbo He, Erwei Chu, Xiang Fan, Yue Cai, Guoyu Lan, Lin Liu, Dai Shi, Li Liang, Jie Yang, Anqi Li, Yalin Zhu, Xin Zhou, Lili Fang, Yiying Wang, Laihong Zhang, Zhen Liu, Ting Ma, for the Alzheimer’s Disease Neuroimaging InitiativeGuanxun Cheng*, Linsen Xu*, Tengfei Guo*, “White matter fractional anisotropy decreases precede hyperintensities in Alzheimer's disease”. Cell Reports Medicine, 2025. DOI: https://doi.org/10.1016/j.xcrm.2025.102138. [Paper]


Guoyu Lan#, Anqi Li#, Fernando Gonzalez-Ortiz, Jieqin Lv, Wenqing Ran, Yue Cai, Pan Sun, Lin Liu, Jie Yang, Laihong Zhang, Zhengbo He, Lili Fang, Xin Zhou, Yalin Zhu, Zhen Liu, Xiang Fan, Xuhui Chen, Linsen Xu, Qingyong Wang, Xinlu Wang, Kun Sun, Guanxun Cheng, Ying Han, Kaj Blennow, Lu Wang*, Pengcheng Ran * ,Tengfei Guo *, “Higher plasma soluble TREM2 correlates with reduced cerebral tau accumulation in Alzheimer’s disease ”. Molecular Psychiatry , 2025. DOI: https://doi.org/10.1038/s41380-025-02976-4.  [Paper ]


Jun Wang#, Shan Huang#, Guoyu Lan#, Yu-Jie Lai#, Qing-Hua Wang, Yang Chen, Zhong-Song Xiao, Xiao Chen, Xian-Le Bu, Yu-Hui Liu, Fan Zeng, Laihong Zhang, Anqi Li, Yue Cai, Pan Sun, Zhengbo He, Vincent Doré, Jurgen Fripp, Pierrick Bourgeat, Qin Chen, Jin-Tai Yu, Yi Tang, Henrik Zetterberg, Colin L. Masters, Tengfei Guo*, Yan-Jiang Wang*, “Diagnostic accuracy of plasma p-tau217/Aβ42 for Alzheimer’s disease in clinical and community cohorts”, Alzheimer’s & Dementia, 2025, DOI: 10.1002/alz.70038. [Paper ]


Yue Cai#, Lili Fang#, Anqi Li, Jie Yang, Xin Zhou, Zhengbo He, Pan Sun, Qingyong Wang* and Tengfei Guo*. “Educational attainment, β-amyloid, tau, and structural brain reserve in Alzheimer’s disease”, Alzheimer’s & Dementia, 2025, DOI: 10.1002/alz.14400. [Paper ]


Guoyu Lan, Laihong Zhang , Anqi Li, Wenqing Ran, Jieqin Lv, Fernando Gonzalez-Ortiz, Yue Cai, Pan Sun, Lin Liu, Jie Yang, Zhengbo He, Lili Fang, Xin Zhou, Yalin Zhu, Zhen Liu, Xuhui Chen, Xiang Fan, Dai Shi , Chenghui Ye, Linsen Xu, Qingyong Wang, Kaj Blennow, Guanxun Cheng; Alzheimer's Disease Neuroimaging Initiative; Pengcheng Ran*, Lu Wang*Tengfei Guo*. “Plasma N-terminal tau fragment is an amyloid-dependent biomarker in Alzheimer's disease”Alzheimer’s & Dementia. 2025, DOI: 10.1002/alz.14550.[Paper ]


Xiaoxie Mao #, Anqi Li#, Ying Wang#, Yan Wang, Shuhua Ren, Kun He, Yihui Guan, Qi Huang, Qihao Guo, Zijing Li*, Tengfei Guo*, Fang Xie*.Association of objective subtle cognitive difficulties with amyloid-β and tau deposition compared to subjective cognitive decline”, European Journal of Nuclear Medicine and Molecular Imaging, 2025, DOI: 10.1007/s00259-025-07080-x. [Paper ]

2024

Pan Sun, Zhengbo He, Anqi Li, Jie Yang, Yalin Zhu, Yue Cai, Ting Ma, Shaohua Ma, Tengfei Guo*. “Spatial and Temporal Patterns of Cortical Mean Diffusivity in Alzheimer’s Disease and Suspected Non-Alzheimer’s Disease Pathophysiology”, Alzheimer’s & Dementia, 2024, doi: 10.1002/alz.14176.[Paper]


Tengfei Guo*, Anqi Li, Pan Sun, Zhengbo He, Yue Cai, Guoyu Lan, Lin Liu, Jieyin Li, Jie Yang, Yalin Zhu, Ruiyue Zhao, Xuhui Chen, Dai Shi, Zhen Liu, Qingyong Wang, Linsen Xu, Liemin Zhou, Pengcheng Ran, Xinlu Wang, Kun Sun, Jie Lu*, Ying Han*. “Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease”, Molecular Neurodegeneration, 2024, 19 (58).doi: 10.1186/s13024-024-00750-8. [Paper]


Anqi Li, Ruiyue Zhao, Mingkai Zhang, Pan Sun, Yue Cai, Lin Zhu, Hank Kung, Ying Han, Xinlu Wang*, Tengfei Guo*. “[18F]-D3FSP β-amyloid PET imaging in older adults and Alzheimer’s disease”, European Journal of Nuclear Medicine and Molecular Imaging, 2024, doi: 10.1007/s00259-024-06835-2.[Paper]


Zhen Liu#, Dai Shi#, Yue Cai, Anqi Li, Guoyu Lan, Pan Sun, Lin Liu, Yalin Zhu, Jie Yang, Yajing Zhou, Lizhi Guo, Laihong Zhang, Shuqing Deng, Shuda Chen, Xianfeng Yu, Xuhui Chen, Ruiyue Zhao, Qingyong Wang, Pengcheng Ran, Linsen Xu, Liemin Zhou, Kun Sun, Xinlu Wang, Qiyu Peng, Ying Han, Tengfei Guo* “Pathophysiology characterization of Alzheimer’s disease in South China’s aging population: for the Greater-Bay-Area Healthy Aging Brain Study (GHABS)”. Alzheimer's Research & Therapy 2024. doi: 10.1186/s13195-024-01458-z.[Paper] 


Yue CaiDai Shi, Guoyu Lan, Linting Chen, Yanni Jiang, Liemin Zhou, Tengfei Guo*. “Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults without Dementia”.  Neurology 2024.doi:10.1212/WNL.0000000000209205.[Paper]


Guoyu Lan, Xuhui Chen, Jie Yang, Pan Sun, Yue Cai, Anqi Li, Yalin Zhu, Zhen Liu, Shaohua Ma, Tengfei Guo*. “Microglial reactivity correlates to presynaptic loss independent of β-amyloid and tau”. Annals of Neurology, 2024, DOI: 10.1002/ana.26885.[Paper]


Xianfeng Yu, Xia Zhou, Zhengbo He, Beiqi He, Ke Wan, Min Wei, Tengfei Guo*, Ying Han*. “Sleep and APOE-ε4 have a synergistic effect on plasma biomarkers and longitudinal cognitive decline in older adults”. CNS Neuroscience & Therapeutics, 2024,30 (2): e14558. [Paper]


2023

Anqi Li, Jing Du, Yue Cai, Xuhui Chen, Kun Sun, Tengfei Guo*, "Body Mass Index Decrease Has a Distinct Association with Alzheimer’s Disease Pathophysiology in APOE Ɛ4 Carriers and Non-Carriers".  Journal of Alzheimer's Disease, 2023. vol. Pre-press, pp. 1-13.[Paper]


Guoyu Lan, Jing Du, Xuhui Chen, Qingyong Wang, for the Alzheimer’s Disease Neuroimaging Initiative, Ying Han, Tengfei Guo*. “Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline”, Neurobiology of Aging, 2023 [Paper]


Jing Du, Anqi Li, Dai Shi, Xuhui Chen, Qingyong Wang, Zhen Liu, Kun Sun, and Tengfei Guo*. "Association of APOE4, Osteoarthritis, Β-Amyloid, and Tau Accumulation in Primary Motor and Somatosensory Regions in Alzheimer Disease." Neurology, 2023, 101(1): e40-e49. [Paper]


Guoyu Lan. and Tengfei Guo*, Reply to: “Aberrant GAP43 Gene Expression Is Alzheimer Disease Pathology-Specific”. Annals of Neurology, 2023, 93: 1049-1049. [Paper]


Yue Cai, Jing Du, Anqi Li, Yalin Zhu, Linsen Xu, Kun Sun, Shaohua Ma, Tengfei Guo*. Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease”, Alzheimer’s Research & Therapy, 2023, 15, 30. [Paper]

2022

Guoyu Lan, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo*, and for the Alzheimer's Disease Neuroimaging Initiative. "Presynaptic Membrane Protein Dysfunction Occurs Prior to Neurodegeneration and Predicts Faster Cognitive Decline." Alzheimer's & Dementia (2022). [Paper]


Guoyu Lan, Yue Cai, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo*, and for the Alzheimer's Disease Neuroimaging Initiative. "Association of presynaptic loss with Alzheimer's disease and cognitive decline", Annals of Neurology (2022). [Paper]


Dai Shi, Siwei Xie, Anqi Li, Qingyong Wang, Hongbo Guo, Ying Han, Huaxi Xu, Wen-Biao Gan, Lei Zhang, Tengfei Guo* for the Alzheimer’s Disease Neuroimaging Initiative. "APOE-ε4 modulates the association among plasma Aβ42/Aβ40, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults." Translational Psychiatry (2022). [Paper]


Chenyang Jiang,  Qingyong Wang,  Siwei Xie,  Zhicheng Chen,  Liping Fu,  Qiyu Peng, Ying Liang,  Hongbo Guo,  Tengfei Guo*. "β-amyloid discordance of cerebrospinal fluid and PET imaging shows distinct spatial tau patterns. " Brain Communications (2022). [Paper]


2021

Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative. "Age, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults."Alz Res Therapy 13, 174 (2021).[Paper]


Yoon, Bora, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J. Ward, Susan M. Landau, William J. Jagust, and Alzheimer's Disease Neuroimaging Initiative. "Abnormal tau in amyloid PET negative individuals." Neurobiology of Aging (2021).[Paper]


Conferences

Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative; CSF p-Tau/Aβ40 ratio predicts longitudinal hypometabolism and cognitive decline in amyloid negative elderly adults (Oral presentation). Alzheimer’s Association International Conference 2021, July 26-30, 2021, visually.


Dai Shi, Lei Zhang, Tengfei Guo, for the Alzheimer’s Disease Neuroimaging Initiative; High precision plasma Aβ42/Aβ40 ratio detects early amyloid deposition in non-demented elderly adults. Alzheimer’s Association International Conference 2021, July 26-30, 2021, visually.

2020

Tengfei Guo*, Deniz Korman, Renaud La Joie, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, for the Alzheimer's . "Normalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer’s disease." Alzheimer's Research & Therapy, 12.1 (2020): 1-15.[Paper]  


Tengfei Guo*, Deniz Korman, Suzanne L. Baker, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative; "Longitudinal cognitive and biomarker measurements support a unidirectional pathway in Alzheimer’s Disease pathophysiology". Biological psychiatry, July 2020.[Paper 


Tengfei Guo*, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, for the Alzheimer’s Disease Neuroimaging Initiative; "Association of CSF Aβ, amyloid PET and cognition in cognitively unimpaired elderly adults". Neurology, August, 2020.[Paper]  


Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative, “Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults”. Neurology, 2020, 94 (14) e1512-e1524.[Paper]    


Conferences  

Tengfei Guo*, Deniz Korman, Renaud La Joie, Leslie M. Shaw, John Q. Trojanowski William J. Jagust, Susan M. Landau, for the Alzheimer’s Disease Neuroimaging Initiative; CSF p-Tau/Aβ40 adjusts for the variance of CSF production and predicts brain tau accumulation in Alzheimer’s disease. Alzheimer’s Association International Conference 2020, July 27-31, 2020.  


Tengfei Guo*, Susan M. Landau, William J. Jagust, for the Alzheimer’s Disease Neuroimaging Initiative; CSF p-Tau detects cerebral tau accumulation earlier than tau PET in amyloid positive elderly adults. The 14th Human Amyloid Imaging, Miami, Florida, January 16-18, 2020.