GUO LABORATORY 
Aging, Alzheimer's Disease, Biomarker, Neuroimaging

CN
Our new paper was published in top journal Neurology as Research Article in 15 May 2023
Posted onMay 16,2023

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Jing Du’s latest paper was published in NeurologyThis paper investigated how osteoarthritis and APOE-ε4 influence the accumulation of β-amyloid (Aβ) and tau accumulation in primary motor and somatosensory regions in Aβ-positive (Aβ+) elderly adults. Neither osteoarthritis nor APOE-ε4 was related to baseline FBP SUVR in precentral and postcentral regions. At follow-up, osteoarthritis rather than APOE-ε4 was associated with faster Aβ accumulation in postcentral (β=0.005[95% ci, 0.001, 0.008]) over time. In addition, osteoarthritis but not the APOE-ε4 allele was strongly linked to higher follow-up FTP tau levels in precentral (β=0.098[95% ci, 0.034, 0.162]) and postcentral (β=0.105[95% ci, 0.040, 0.169]) cortices. OA and APOE-ε4 were also interactively associated with higher follow-up FTP tau deposition in precentral (β=0.128[95% ci, 0.030, 0.226]) and postcentral (β=0.124[95% ci, 0.027, 0.223]) regions. This study suggests that OA was associated with faster Aβ accumulation and higher Aβ-dependent future tau deposition in primary motor and somatosensory regions, providing novel insights into how OA increases the risk of AD.