Aging, Alzheimer's Disease, Biomarker, Neuroimaging

About us

The Guo Lab

The Guo Lab is a joint research program involving the Shenzhen Bay Laboratory (SZBL) and Peking University Shenzhen Graduate School (PKUSZ). Alzheimer’s disease (AD) is a neurodegenerative disease, accounting for 60-80% of the cause of dementia. β-amyloid- (Aβ) plaques and neurofibrillary tangles are the two key hallmarks of AD, and appear 15-20 years before the presence of manifest clinical symptoms. The advances of positron emission tomography (PET) imaging and biofluid markers including plasma and cerebrospinal fluid (CSF) assays make it possible to measure Aβ and tau deposition in vivo in the very early stage of AD. It has been commonly suggested that early detection of abnormal Alzheimer's pathologies changes is extremely important for the intervention of the disease progression. 


The Guo lab is engaged in the study of how Aβ and tau affect brain structure and function in aging people and AD patients using multi-model neuroimaging and biofluid markers including plasma and cerebrospinal fluid (CSF) assays. In SZBL and PKUSZ, neuroscientists, engineers, computer scientists and neurologists work together to investigate the risk factors of Aβ and tau accumulation, and how Aβ and tau result in neurodegeneration and cognitive decline in aging people’s brain. The ultimate goal is to detect this disease as early as possible and provide novel insights into the early diagnosis and prevention of AD.